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Reynolds and colleagues observed that patients with low serum folate levels undergoing treatment with various antidepressant drugs had poorer therapeutic outcomes (19, 30, 65)

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The pellet was air dried and dissolved in 1 mM sodium acetate (pH 5.2) before use

Several pharmacological strategies, including erythropoiesis-stimulating agents, vitamin D analogs, phosphate binders, and anti-inflammatory agents, have been evaluated in interventional and observational studies, primarily targeting metabolic and inflammatory parameters (9)

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